It might not be now-or-never desperation for the Houston Texans just yet when they host the Indianapolis Colts on Sunday in a key AFC South clash to open the regular season. But the Texans know they will likely need to beat the Colts at least once in order to gain enough confidence to be a playoff team for the first time in their existence this year. Indy is a small road favorite at -2 depending where you shop thanks to past dominance in the series. This line is hovering from -1 to -2 so be sure to get the best number depending on the side you like. You can compare the current odds on our NFL point spreads page of the website for free.
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