The Bills are currently a 3.5 point favorite in the NFL odds against the Colts tonight.
The Indianapolis Colts (0-1) and Buffalo Bills (0-1) meet for the first time since the 2009 regular-season finale, and if you watched that game then you will understand why the home team is favored yet again in this preseason matchup.  The Bills were -9 on the NFL point spread in the last meeting and dominated the Colts in a 30-7 rout as Indy backup QB Curtis Painter struggled mightily after Peyton Manning left the game.

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