MLB Betting Odds and Predictions: San Diego Padres vs. Boston Red Sox

The San Diego Padres (40-44) and Boston Red Sox (51-34) will continue a three-game MLB interleague series Wednesday night at Fenway Park, with the first pitch scheduled for 7:10 p.m. ET

San Diego Padres vs. Boston Red Sox

The Boston Red Sox are 4-1 as home favorites of -175 to -200 this season

San Diego has lost four games in a row, including a 4-1 setback to Boston as +197 road underdogs Tuesday, while going UNDER the betting total for a second consecutive contest. The Padres are now four games under .500 for the first time since June 10, but are still in good position to make a run in the National League West division. The club is 25-30 in July the last two-plus seasons, with the OVER going 31-23-1 in that situation.

Padres starting pitcher Edinson Volquez (6-6, 5.50 ERA) is coming off a 9-2 road victory over the Miami Marlins last time out, as he allowed two runs and seven hits over six frames. The right-hander is 3-2 with a 6.23 ERA in nine road outings, with opposing batters hitting .314 against him. Volquez didn’t earn a decision in his only career start against the Red Sox in 2008, as he surrendered three runs (two earned) in seven innings of work.

Boston has won six of its last seven games, while the UNDER has cashed in its last three affairs. The Red Sox are now 29-16 at home this season, as they lead all of baseball in extra-base hits and rank second in batting average in that situation. The club is 5-2 versus National League opponents this season and has won 14 of its last 18 games in that particular role. Boston is 4-1 as home favorites of -175 to -200 this season, with the OVER going 3-2 in those five opportunities.

Red Sox starting pitcher Jon Lester (8-4, 4.61 ERA) has won back-to-back outings, including a 7-4 home victory over the Toronto Blue Jays last time out, as he allowed four runs and five hits over seven frames. The left-hander is 3-0 with a 3.24 ERA in six home outings, surrendering three home runs in 41.2 combined innings. Lester will be facing the Padres for the first time in his career.